Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function.

The 26S proteasome of eukaryotic cells mediates ubiquitin-dependent as well as ubiquitin-independent degradation of proteins in many regulatory processes as well as in protein quality control. The proteasome itself is a dynamic complex with varying compositions and interaction partners. Studies in Saccharomyces cerevisiae have revealed that expression of proteasome subunit genes is coordinately...

متن کامل

Outsourcing suppliers as downstream competitors: Biting the hand that feeds

In this paper, we highlight an aspect of supplier opportunism in the outsourcing paradox that has largely been ignored by extant research – the supplier as a direct competitor of the buyer firm. In light of this paradox, we offer a game-theoretic framework in which we identify conditions under which firms could alleviate or mitigate this outsourcing problem. Our results show that apart from tra...

متن کامل

Blood donor deferrals: biting the hand that feeds us!

I n this issue of TRANSFUSION, the article by Zou and colleagues details trends in donor deferral and retention using the American Red Cross database. The power of the study is the enormous experience culled from almost half the nation’s blood supply. Prominent among the observations are the increasing deferrals for failing to achieve minimum hemoglobin (Hb)/ hematocrit (Hct) criteria and for d...

متن کامل

Proteasome assembly: Biting the hand…

Proteasome assembly is regulated to ensure the enzyme is inactive until its active sites are compartmentalized within an interior aqueous chamber. In yeast, this depends on a dedicated chaperone that is trapped within the nascent proteasome, and degraded on maturation of the proteolytic subunits.

متن کامل

PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you?

MOST MEMBRANE RECEPTORS in mammalian systems are seventransmembrane domain G protein-coupled receptors. Proteinase (or protease)-activated receptors (PARs) are a novel family of G protein-coupled receptors. Unlike other G protein-coupled receptors that require ligand binding for activation, PARs are activated upon cleavage of their extracellular NH2 terminus by serine proteases such as thrombin...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

سال: 2007

ISSN: 0167-4889

DOI: 10.1016/j.bbamcr.2007.05.015